Carcinogenesis, Teratogenesis & Mutagenesis ›› 1999, Vol. 11 ›› Issue (2): 91-093.doi: 10.3969/j.issn.1004-616x.1999.02.009

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STUDY ON MUTAGENICITY OF ETHREL

Zhao Su , Duan Zhiwen , J in Huanrong et al   

  1. Department of Occupational heal th , S hengyang Medical College , S hengyang  110031
  • Received:1900-01-01 Revised:1900-01-01 Online:1999-03-30 Published:1999-03-30

Abstract: The mutagenicity of Ethrel was studied by Ames test , sperm deformity test and marrow micronucleus test in mice. The result s showed that Ames test was negative , but the rates of marrow cells micronucleus and spermatic deformity in high dosage group were increased and statistically significant difference was observed between t reated and cont rol groups. It is indicated that Ethrel has potential mutagenicity for somatic cells and reproductive cells in mice.

Key words: Ethrel, Ames test, Marrow micronucleus test, Sperm deformity test, mice